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Molbank 2015, 2015(4), M870; doi:10.3390/M870


Faculty of Chemistry and Pharmacy, University of Sofia “St. Kl. Ohridski”, 1, James Bourchier Blvd., 1164 Sofia, Bulgaria
Author to whom correspondence should be addressed.
Received: 30 September 2015 / Revised: 21 October 2015 / Accepted: 27 October 2015 / Published: 29 October 2015
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We report a novel protocol for the synthesis of 3-(3,4-dihydroxyphenyl)-8-hydroxy-2H-chromen-2-one via demethylation/delactonization/elimination/lactonization/ decarboxylation domino reaction sequence of diastereomeric mixture of cis- and trans-3-(2,3-dimethoxyphenyl)-6,7-dimethoxy-1-oxoisochroman-4-carboxylic acids in boiling HBr/AcOH. The structure of the target compound was established for the first time by means of spectral methods such as 1H-, 13C-, DEPT-135-NMR, IR and HRMS. View Full-Text
Keywords: polyhydroxylated 3-arylcoumarins; 3,4-dihydroisocoumarin; domino reaction polyhydroxylated 3-arylcoumarins; 3,4-dihydroisocoumarin; domino reaction

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Svinyarov, I.; Bogdanov, M. 3-(3,4-Dihydroxyphenyl)-8-hydroxy-2H-chromen-2-one. Molbank 2015, 2015, M870.

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