Open AccessShort Note
Received: 30 April 2015 / Revised: 30 June 2015 / Accepted: 1 July 2015 / Published: 10 July 2015
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A one-pot, direct synthesis of 3,4-dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H
)-one from methyl (2-formylphenyl)carbamate, ethanolamine and nitromethane in AcOH is reported. The reaction proceeds via a cascade three-component aza
-Henry reaction under microwave irradiation and the title compound was characterized by 1
H NMR, 13
C NMR and ESI/MS analysis.