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• Hanafi, M
• Yanuar, A
• Hudiyono, S
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• Yanuar, A
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Molbank 2012, 2012(3), M765; doi:10.3390/M765

Short Note

2-Methoxy-5-{4-oxo-2-[(E)-2-(4-sulfamoylphenyl)ethenyl-3,4-dihydroquinazolin-3-yl]benzene-1-sulfonamide

Hayun ^1,* , Muhammad Hanafi ² , Arry Yanuar ¹  and Sumi Hudiyono ³

¹ Department of Pharmacy, Faculty of Natural Sciences, University of Indonesia, Depok, 16424, West Java, Indonesia ² Research Center for Chemistry, Indonesian Institute of Sciences, Serpong, 15314, Indonesia ³ Department of Chemistry, Faculty of Natural Sciences, University of Indonesia, Depok, 16424, West Java, Indonesia

* Author to whom correspondence should be addressed.

Received: 2 May 2012 / Accepted: 11 July 2012 / Published: 18 July 2012

Download PDF Full-Text [74 KB, uploaded 18 July 2012 10:41 CEST]

Abstract: The title compound, 2-methoxy-5-{4-oxo-2-[(E)-2-(4-sulfamoylphenyl) ethenyl-3, 4-dihydroquinazolin-3-yl] benzene-1-sulfonamide 2 has been synthesized by the reaction of 3-(4-methoxyphenyl)-2-styryl-4(3H)-quinazolinone 1 with an excess of chlorosulfonic acid, followed by amidation of the sulfonyl chloride product with ammonia gas. The structure of the synthesized compound was confirmed on the basis of IR, ¹H-NMR, ¹³C-NMR and mass spectral data.

Keywords: 4(3H)-quinazolinone; 2-styryl-4(3H)-quinazolinone; benzenesulfonamide; chlorosulfonation-amidation

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