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Molbank 2010, 2010(3), M695; doi:10.3390/M695


Research Department of Chemistry, SRM University, Ramapuram Campus, Chennai-89, Tamil Nadu, India
Author to whom correspondence should be addressed.
Received: 25 June 2010 / Accepted: 14 September 2010 / Published: 16 September 2010
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This present work aims at synthesizing a novel tetrazole from quinazolinone. 3-(4-Aminophenyl)-2-methyl-3H-quinazolin-4-one is converted into a nitrile by reacting it with acrylonitrile and triton B. The nitrile on treatment with NaN3, NH4Cl and DMF yielded the corresponding tetrazole. The tetrazole obtained was characterized by IR, 1H NMR, EI-MS and elemental analysis. The compound was screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger.The results of the study show that the compound possesses fairly good antimicrobial activity against the test organisms.
Keywords: quinazolinone; tetrazole; antimicrobial quinazolinone; tetrazole; antimicrobial

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Arulmurugan, S.; Kavitha, H.P. 2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one. Molbank 2010, 2010, M695.

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