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Molbank 2009, 2009(4), M645; doi:10.3390/M645
Short Note

Methyl 6-Methyl-4-(4-iodophenyl)-1,2,3,4-tetrahydro-2-thioxo-5-pyrimidinecarboxylate

,  and *
Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, College of Chemistry, Shandong Normal University, Jinan 250014, China
* Author to whom correspondence should be addressed.
Received: 23 October 2009 / Accepted: 11 December 2009 / Published: 15 December 2009
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Abstract

Methyl 6-methyl-4-(4-iodophenyl)-1,2,3,4-tetrahydro-2-thioxo-5-pyrimidinecarboxylate has been synthesized via Biginelli reaction of 4-iodobenzaldehyde, methyl acetoacetate and thiourea, promoted by microwave irradiation in the presence of iodine under solvent-free conditions in high yield and good purity.
Keywords: Biginelli reaction; solvent-free conditions; microwave irradiation; 3,4-dihydropyrimidin-2(1H)-thione Biginelli reaction; solvent-free conditions; microwave irradiation; 3,4-dihydropyrimidin-2(1H)-thione
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pan, N.; Zhang, W.; Liu, Q. Methyl 6-Methyl-4-(4-iodophenyl)-1,2,3,4-tetrahydro-2-thioxo-5-pyrimidinecarboxylate. Molbank 2009, 2009, M645.

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