Molbank 2009, 2009(1), M590; doi:10.3390/M590
Short Note

Synthesis of 3-(4-Chloro-2-methoxy-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)propanoic acid – An N(9)-Functionalized 7-Deazapurine

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Received: 13 January 2009; Accepted: 30 January 2009 / Published: 6 February 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Regioselective N-alkylation of 4-chloro-2-methoxy-7H-pyrrolo[2,3- d]pyrimidine (6) with ethyl 3-bromopropionate under liquid-liquid phase-transfer reactionconditions gave the ester 7a. Its saponification yielded the acid 7b. The logP values of a series of N(9)-functionalized purines and purine isosteres were calculated.
Keywords: 7-Deazapurines; pyrrolo[2; 3-d]pyrimidines; functionalization; phase-transfer alkylation; logP values
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MDPI and ACS Style

Rosemeyer, H. Synthesis of 3-(4-Chloro-2-methoxy-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)propanoic acid – An N(9)-Functionalized 7-Deazapurine. Molbank 2009, 2009, M590.

AMA Style

Rosemeyer H. Synthesis of 3-(4-Chloro-2-methoxy-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)propanoic acid – An N(9)-Functionalized 7-Deazapurine. Molbank. 2009; 2009(1):M590.

Chicago/Turabian Style

Rosemeyer, Helmut. 2009. "Synthesis of 3-(4-Chloro-2-methoxy-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)propanoic acid – An N(9)-Functionalized 7-Deazapurine." Molbank 2009, no. 1: M590.

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