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Broad-Spectrum Drugs Against Viral Agents
Defence Research & Development Canada – Suffield, Box 4000, Station Main, Medicine Hat, AB, Canada
* Author to whom correspondence should be addressed.
Received: 18 April 2008; Accepted: 29 August 2008 / Published: 1 September 2008
Abstract: Development of antivirals has focused primarily on vaccines and on treatments for specific viral agents. Although effective, these approaches may be limited in situations where the etiologic agent is unknown or when the target virus has undergone mutation, recombination or reassortment. Augmentation of the innate immune response may be an effective alternative for disease amelioration. Nonspecific, broad-spectrum immune responses can be induced by double-stranded (ds)RNAs such as poly (ICLC), or oligonucleotides (ODNs) containing unmethylated deocycytidyl-deoxyguanosinyl (CpG) motifs. These may offer protection against various bacterial and viral pathogens regardless of their genetic makeup, zoonotic origin or drug resistance.
Keywords: CpG; cytokine; influenza; poly (ICLC); TLR
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Christopher, M.E.; Wong, J.P. Broad-Spectrum Drugs Against Viral Agents. Int. J. Mol. Sci. 2008, 9, 1561-1594.
Christopher ME, Wong JP. Broad-Spectrum Drugs Against Viral Agents. International Journal of Molecular Sciences. 2008; 9(9):1561-1594.
Christopher, Mary E.; Wong, Jonathan P. 2008. "Broad-Spectrum Drugs Against Viral Agents." Int. J. Mol. Sci. 9, no. 9: 1561-1594.