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• Malavolta, L
• Poletti, EF.
• Silva, EH.
• Schreier, S
• Nakaie, CR.
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• Malavolta, L
• Poletti, EF.
• Silva, EH.
• Schreier, S
• Nakaie, CR.
• [+] on PubMed
• Malavolta, L
• Poletti, EF.
• Silva, EH.
• Schreier, S
• Nakaie, CR.

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Int. J. Mol. Sci. 2008, 9(7), 1321-1332; doi:10.3390/ijms9071321

Article

Application of Electron Paramagnetic Resonance Spectroscopy for Validation of the Novel (AN+DN) Solvent Polarity Scale

Luciana Malavolta ^1,3 , Erick F. Poletti ¹ , Elias H. Silva ¹ , Shirley Schreier ²  and Clovis R. Nakaie ^1,*

¹ Department of Biophysics, Universidade Federal de Sao Paulo (Unifesp), Rua 3 de Maio 100, CEP 04044-020, São Paulo, SP, Brazil ² Department of Biochemistry, Institute of Chemistry, Universidade de Sao Paulo, Sao Paulo, Brazil ³ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sao Paulo, SP, Brazil

* Author to whom correspondence should be addressed.

Received: 24 April 2008; in revised form: 3 July 2008 / Accepted: 4 July 2008 / Published: 17 July 2008

(This article belongs to the Section Physical Chemistry, Theoretical and Computational Chemistry)

Download PDF Full-Text [361 KB, uploaded 2 October 2008 12:05 CEST]

Abstract: Based on solvation studies of polymers, the sum (1:1) of the electron acceptor (AN) and electron donor (DN) values of solvents has been proposed as an alternative polarity scale. To test this, the electron paramagnetic resonance isotropic hyperfine splitting constant, a parameter known to be dependent on the polarity/proticity of the medium, was correlated with the (AN+DN) term using three paramagnetic probes. The linear regression coefficient calculated for 15 different solvents was approximately 0.9, quite similar to those of other well-known polarity parameters, attesting to the validity of the (AN+DN) term as a novel “two-parameter” solvent polarity scale.

Keywords: polarity; solvent; EPR; spin label; isotropic hyperfine splitting constant

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