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Betulinic Acid for Cancer Treatment and Prevention
University Children’s Hospital, Eythstr. 24, 89075 Ulm, Germany
Received: ; in revised form: / Accepted: / Published: 27 June 2008
Abstract: Betulinic acid is a natural product with a range of biological effects, for example potent antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell death in cancer cells by triggering the mitochondrial pathway of apoptosis. In contrast to the cytotoxicity of betulinic acid against a variety of cancer types, normal cells and tissue are relatively resistant to betulinic acid, pointing to a therapeutic window. Compounds that exert a direct action on mitochondria present promising experimental cancer therapeutics, since they may trigger cell death under circumstances in which standard chemotherapeutics fail. Thus, mitochondrion-targeted agents such as betulinic acid hold great promise as a novel therapeutic strategy in the treatment of human cancers.
Keywords: apoptosis; cancer; betulinic acid; mitochondria
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Cite This Article
MDPI and ACS Style
Fulda, S. Betulinic Acid for Cancer Treatment and Prevention. Int. J. Mol. Sci. 2008, 9, 1096-1107.
Fulda S. Betulinic Acid for Cancer Treatment and Prevention. International Journal of Molecular Sciences. 2008; 9(6):1096-1107.
Fulda, Simone. 2008. "Betulinic Acid for Cancer Treatment and Prevention." Int. J. Mol. Sci. 9, no. 6: 1096-1107.