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Int. J. Mol. Sci. 2008, 9(6), 1096-1107; doi:10.3390/ijms9061096
Review

Betulinic Acid for Cancer Treatment and Prevention

Published: 27 June 2008
(This article belongs to the Special Issue Natural Compounds for Cancer Treatment and Prevention)
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Abstract: Betulinic acid is a natural product with a range of biological effects, for example potent antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell death in cancer cells by triggering the mitochondrial pathway of apoptosis. In contrast to the cytotoxicity of betulinic acid against a variety of cancer types, normal cells and tissue are relatively resistant to betulinic acid, pointing to a therapeutic window. Compounds that exert a direct action on mitochondria present promising experimental cancer therapeutics, since they may trigger cell death under circumstances in which standard chemotherapeutics fail. Thus, mitochondrion-targeted agents such as betulinic acid hold great promise as a novel therapeutic strategy in the treatment of human cancers.
Keywords: apoptosis; cancer; betulinic acid; mitochondria apoptosis; cancer; betulinic acid; mitochondria
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fulda, S. Betulinic Acid for Cancer Treatment and Prevention. Int. J. Mol. Sci. 2008, 9, 1096-1107.

AMA Style

Fulda S. Betulinic Acid for Cancer Treatment and Prevention. International Journal of Molecular Sciences. 2008; 9(6):1096-1107.

Chicago/Turabian Style

Fulda, Simone. 2008. "Betulinic Acid for Cancer Treatment and Prevention." Int. J. Mol. Sci. 9, no. 6: 1096-1107.


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