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Int. J. Mol. Sci. 2008, 9(5), 906-913; doi:10.3390/ijms9050906
Article

Headspace Solid Phase Micro Extraction Gas Chromatographic Determination of Fenthion in Human Serum

1,* , 2, 1, 2
, 3
, 4
 and 1
1 Benaki Phytopathological Institute, Laboratory of Pesticides Toxicology, 8 St. Delta Street, Kifissia 14561, Athens, Greece 2 Pharmacology Department, Medical School, University of Athens, 115 27, Athens, Greece 3 Agroindustrial Robola Growers Cooperative of Kefalllinia, Omala, 28100 Kefallinia, Greece 4 Chemistry Laboratory, Agricultural University of Athens, Iera Odos 75, 118 55, Athens, Greece
* Author to whom correspondence should be addressed.
Received: 15 April 2008 / Revised: 22 May 2008 / Accepted: 23 May 2008 / Published: 23 May 2008
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Abstract

A simple and effective analytical procedure was developed for the determination of fenthion residues in human serum samples. The sample treatment was performed using the headspace solid-phase micro extraction with polyacrylate fiber, which has the advantage to require low amount of serum (1 mL) without tedious pre-treatment. The quantification of fenthion was carried out by gas chromatography-mass spectrometry and the recoveries ranged from 79 to 104% at two spiking levels for 6 replicates. Detection and quantification limits were calculated as 1.51 and 4.54 ng/mL of serum respectively. Two fenthion metabolites − fenoxon and fenthion–sulfoxide − were also identified.
Keywords: Insecticide residue; olive; fenthion; headspace; SPME; GC/MS; metabolites. Insecticide residue; olive; fenthion; headspace; SPME; GC/MS; metabolites.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kasiotis, K.M.; Souki, H.; Tsakirakis, A.N.; Carageorgiou, H.; Theotokatos, S.A.; Haroutounian, S.A.; Machera, K. Headspace Solid Phase Micro Extraction Gas Chromatographic Determination of Fenthion in Human Serum. Int. J. Mol. Sci. 2008, 9, 906-913.

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