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Remarks on Muscle Contraction Mechanism
Osaka University, Japan
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
* Author to whom correspondence should be addressed.
Received: 14 November 2007; in revised form: 19 May 2008 / Accepted: 19 May 2008 / Published: 23 May 2008
Abstract: Muscle contraction mechanism is discussed by reforming the model described in an article by Mitsui (Adv. Biophys. 1999, 36, 107-158). A simple thermodynamic relationship is presented, which indicates that there is an inconsistency in the power stroke model or the swinging lever model. To avoid this difficulty, a new model is proposed. It is assumed that a myosin head forms a polaron-like complex with about three actin molecules when it attaches to an actin filament and the complex translates along the actin filament producing force. Various experimental data on the muscle contraction are well explained based upon the model.
Keywords: muscle contraction mechanism; theory; difficulty of the power stroke model; polaron-like model; X-ray equatorial Bragg reflections; tension dependence of muscle stiffness; force-velocity relation; energy liberation rate; isometric tension transient; isotonic velocity transient.
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MDPI and ACS Style
Mitsui, T.; Ohshima, H. Remarks on Muscle Contraction Mechanism. Int. J. Mol. Sci. 2008, 9, 872-904.
Mitsui T, Ohshima H. Remarks on Muscle Contraction Mechanism. International Journal of Molecular Sciences. 2008; 9(5):872-904.
Mitsui, Toshio; Ohshima, Hiroyuki. 2008. "Remarks on Muscle Contraction Mechanism." Int. J. Mol. Sci. 9, no. 5: 872-904.