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Int. J. Mol. Sci. 2008, 9(5), 872-904; doi:10.3390/ijms9050872
Article

Remarks on Muscle Contraction Mechanism

1,*  and 2
Received: 14 November 2007; in revised form: 19 May 2008 / Accepted: 19 May 2008 / Published: 23 May 2008
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Abstract: Muscle contraction mechanism is discussed by reforming the model described in an article by Mitsui (Adv. Biophys. 1999, 36, 107-158). A simple thermodynamic relationship is presented, which indicates that there is an inconsistency in the power stroke model or the swinging lever model. To avoid this difficulty, a new model is proposed. It is assumed that a myosin head forms a polaron-like complex with about three actin molecules when it attaches to an actin filament and the complex translates along the actin filament producing force. Various experimental data on the muscle contraction are well explained based upon the model.
Keywords: muscle contraction mechanism; theory; difficulty of the power stroke model; polaron-like model; X-ray equatorial Bragg reflections; tension dependence of muscle stiffness; force-velocity relation; energy liberation rate; isometric tension transient; isotonic velocity transient. muscle contraction mechanism; theory; difficulty of the power stroke model; polaron-like model; X-ray equatorial Bragg reflections; tension dependence of muscle stiffness; force-velocity relation; energy liberation rate; isometric tension transient; isotonic velocity transient.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mitsui, T.; Ohshima, H. Remarks on Muscle Contraction Mechanism. Int. J. Mol. Sci. 2008, 9, 872-904.

AMA Style

Mitsui T, Ohshima H. Remarks on Muscle Contraction Mechanism. International Journal of Molecular Sciences. 2008; 9(5):872-904.

Chicago/Turabian Style

Mitsui, Toshio; Ohshima, Hiroyuki. 2008. "Remarks on Muscle Contraction Mechanism." Int. J. Mol. Sci. 9, no. 5: 872-904.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert