Int. J. Mol. Sci. 2008, 9(4), 498-511; doi:10.3390/ijms9040498
Article

Supported Phospholipid Bilayer Interaction with Components Found in Typical Room-Temperature Ionic Liquids – a QCM-D and AFM Study

New Crops and Processing Technology Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, 1815 N. University Street, Peoria, IL 61604, USA
Received: 16 October 2007; in revised form: 26 February 2007 / Accepted: 14 March 2008 / Published: 4 April 2008
(This article belongs to the Special Issue Ionic Liquids)
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Abstract: Quartz crystal microbalance with dissipation (QCM-D) monitoring and atomic force microscopy (AFM) were combined to evaluate the defects created by an ionic liquid anion and a cation in a supported phospholipid bilayer composed of zwitterionic lipids on a silica surface. The cation 1-octyl-3-methyl imidazolium (OMIM+) was shown to remove lipids from the bilayer, increase the roughness to approximately 2.8 nm (~0.2 for stable supported bilayer) and possibly redeposit lipids with entrapped water. The anion bis(trifluoromethylsulfonyl)imide (Tf2N-) was found to leave distinct defects within the bilayer that had large pore-like interiors which left the surrounding bilayer intact. However, the ionic liquid 1-butyl-1-methyl pyrrolidinium bis(trifluoromethylsulfonyl)imide (BMP-Tf2N) formed a film over the supported bilayer. This work demonstrates, for the first time, the direct effects common components of ionic liquids have on a supported phospholipids bilayer.
Keywords: Quartz crystal microbalance with dissipation (QCM-D); Supported phospholipid bilayer (SPB); Room-temperature ionic liquid (RT-IL); Atomic force microscopy (AFM); 1; 2-dielaidoylphosphatidylcholine (DEPC).

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MDPI and ACS Style

Evans, K.O. Supported Phospholipid Bilayer Interaction with Components Found in Typical Room-Temperature Ionic Liquids – a QCM-D and AFM Study. Int. J. Mol. Sci. 2008, 9, 498-511.

AMA Style

Evans KO. Supported Phospholipid Bilayer Interaction with Components Found in Typical Room-Temperature Ionic Liquids – a QCM-D and AFM Study. International Journal of Molecular Sciences. 2008; 9(4):498-511.

Chicago/Turabian Style

Evans, Kervin O. 2008. "Supported Phospholipid Bilayer Interaction with Components Found in Typical Room-Temperature Ionic Liquids – a QCM-D and AFM Study." Int. J. Mol. Sci. 9, no. 4: 498-511.

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