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Int. J. Mol. Sci. 2008, 9(3), 316-326; doi:10.3390/ijms9030316
Article

Voltammetric Behavior of o-Nitrophenol and Damage to DNA

, , ,  and *
College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China
* Author to whom correspondence should be addressed.
Received: 3 December 2007 / Revised: 15 February 2008 / Accepted: 29 February 2008 / Published: 12 March 2008
(This article belongs to the Special Issue Nucleic Acid Derivatives in Emerging Technologies)
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Abstract

The electrochemical behavior of o-nitrophenol was studied in detail with a glassy carbon electrode (GCE). The dependence of peak potential on pH indicated that equivalent electrons and protons were involved in the process of o-nitrophenol reduction. The interaction of o-nitrophenol with calf thymus DNA was investigated by adding DNA to the o-nitrophenol solution and by immobilizing DNA on GCE, respectively. The peak current decrement and peak potential shift in presence of DNA indicated that o-nitrophenol could interact with DNA. The result was demonstrated that the in situ DNA damage was detected by differential pulse voltammetry after the o-nitrophenol was electrochemically reduced.
Keywords: o-Nitrophenol; DNA-modified GCE; DNA damage; Electrochemical reduction o-Nitrophenol; DNA-modified GCE; DNA damage; Electrochemical reduction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, D.-P.; Wu, W.-L.; Long, H.-Y.; Liu, Y.-C.; Yang, Z.-S. Voltammetric Behavior of o-Nitrophenol and Damage to DNA. Int. J. Mol. Sci. 2008, 9, 316-326.

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