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Int. J. Mol. Sci. 2008, 9(3), 316-326; doi:10.3390/ijms9030316

Voltammetric Behavior of o-Nitrophenol and Damage to DNA

, , ,  and *
College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China
* Author to whom correspondence should be addressed.
Received: 3 December 2007 / Revised: 15 February 2008 / Accepted: 29 February 2008 / Published: 12 March 2008
(This article belongs to the Special Issue Nucleic Acid Derivatives in Emerging Technologies)
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The electrochemical behavior of o-nitrophenol was studied in detail with a glassy carbon electrode (GCE). The dependence of peak potential on pH indicated that equivalent electrons and protons were involved in the process of o-nitrophenol reduction. The interaction of o-nitrophenol with calf thymus DNA was investigated by adding DNA to the o-nitrophenol solution and by immobilizing DNA on GCE, respectively. The peak current decrement and peak potential shift in presence of DNA indicated that o-nitrophenol could interact with DNA. The result was demonstrated that the in situ DNA damage was detected by differential pulse voltammetry after the o-nitrophenol was electrochemically reduced.
Keywords: o-Nitrophenol; DNA-modified GCE; DNA damage; Electrochemical reduction o-Nitrophenol; DNA-modified GCE; DNA damage; Electrochemical reduction
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, D.-P.; Wu, W.-L.; Long, H.-Y.; Liu, Y.-C.; Yang, Z.-S. Voltammetric Behavior of o-Nitrophenol and Damage to DNA. Int. J. Mol. Sci. 2008, 9, 316-326.

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