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Voltammetric Behavior of o-Nitrophenol and Damage to DNA
College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China
* Author to whom correspondence should be addressed.
Received: 3 December 2007; in revised form: 15 February 2008 / Accepted: 29 February 2008 / Published: 12 March 2008
Abstract: The electrochemical behavior of o-nitrophenol was studied in detail with a glassy carbon electrode (GCE). The dependence of peak potential on pH indicated that equivalent electrons and protons were involved in the process of o-nitrophenol reduction. The interaction of o-nitrophenol with calf thymus DNA was investigated by adding DNA to the o-nitrophenol solution and by immobilizing DNA on GCE, respectively. The peak current decrement and peak potential shift in presence of DNA indicated that o-nitrophenol could interact with DNA. The result was demonstrated that the in situ DNA damage was detected by differential pulse voltammetry after the o-nitrophenol was electrochemically reduced.
Keywords: o-Nitrophenol; DNA-modified GCE; DNA damage; Electrochemical reduction
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Zhang, D.-P.; Wu, W.-L.; Long, H.-Y.; Liu, Y.-C.; Yang, Z.-S. Voltammetric Behavior of o-Nitrophenol and Damage to DNA. Int. J. Mol. Sci. 2008, 9, 316-326.
Zhang D-P, Wu W-L, Long H-Y, Liu Y-C, Yang Z-S. Voltammetric Behavior of o-Nitrophenol and Damage to DNA. International Journal of Molecular Sciences. 2008; 9(3):316-326.
Zhang, Da-Peng; Wu, Wei-Li; Long, Hai-Yan; Liu, Yun-Chun; Yang, Zhou-Sheng. 2008. "Voltammetric Behavior of o-Nitrophenol and Damage to DNA." Int. J. Mol. Sci. 9, no. 3: 316-326.