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Int. J. Mol. Sci. 2008, 9(12), 2388-2406; doi:10.3390/ijms9122388
Article

Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress

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Received: 6 November 2008; in revised form: 22 November 2008 / Accepted: 28 November 2008 / Published: 1 December 2008
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: This study was designed to investigate the effect of increased levels of HO-1 on hypertension exacerbated by diabetes. Diabetic spontaneously hypertensive rat (SHR) and WKY (control) animals were treated with streptozotocin (STZ) to induce diabetes and stannous chloride (SnCl2) to upregulate HO-1. Treatment with SnCl2 not only attenuated the increase of blood pressure (p<0.01), but also increased HO-1 protein content, HO activity and plasma adiponectin levels, decreased the levels of superoxide and 3-nitrotyrosine (NT), respectively. Reduction in oxidative stress resulted in the increased expression of Bcl-2 and AKT with a concomitant reduction in circulating endothelial cells (CEC) in the peripheral blood (p<0.005) and an improvement of femoral reactivity (response to acetylcholine). Thus induction of HO-1 accompanied with increased plasma adiponectin levels in diabetic hypertensive rats alters the phenotype through a reduction in oxidative stress, thereby permitting endothelial cells to maintain an anti-apoptotic environment and the restoration of endothelial responses thus preventing hypertension.
Keywords: Heme oxygenase; hypertension; diabetes; adiponectin; oxidative stress; apoptosis Heme oxygenase; hypertension; diabetes; adiponectin; oxidative stress; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cao, J.; Drummond, G.; Inoue, K.; Sodhi, K.; Li, X.Y.; Omura, S. Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress. Int. J. Mol. Sci. 2008, 9, 2388-2406.

AMA Style

Cao J, Drummond G, Inoue K, Sodhi K, Li XY, Omura S. Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress. International Journal of Molecular Sciences. 2008; 9(12):2388-2406.

Chicago/Turabian Style

Cao, Jian; Drummond, George; Inoue, Kazuyoshi; Sodhi, Komal; Li, Xiao Y.; Omura, Shinji. 2008. "Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress." Int. J. Mol. Sci. 9, no. 12: 2388-2406.



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