Int. J. Mol. Sci. 2008, 9(12), 2388-2406; doi:10.3390/ijms9122388
Article

Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress

1 Department of Pharmacology, New York Medical College, Valhalla, NY 10595 USA 2 Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853 China
* Author to whom correspondence should be addressed.
Received: 6 November 2008; in revised form: 22 November 2008 / Accepted: 28 November 2008 / Published: 1 December 2008
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: This study was designed to investigate the effect of increased levels of HO-1 on hypertension exacerbated by diabetes. Diabetic spontaneously hypertensive rat (SHR) and WKY (control) animals were treated with streptozotocin (STZ) to induce diabetes and stannous chloride (SnCl2) to upregulate HO-1. Treatment with SnCl2 not only attenuated the increase of blood pressure (p<0.01), but also increased HO-1 protein content, HO activity and plasma adiponectin levels, decreased the levels of superoxide and 3-nitrotyrosine (NT), respectively. Reduction in oxidative stress resulted in the increased expression of Bcl-2 and AKT with a concomitant reduction in circulating endothelial cells (CEC) in the peripheral blood (p<0.005) and an improvement of femoral reactivity (response to acetylcholine). Thus induction of HO-1 accompanied with increased plasma adiponectin levels in diabetic hypertensive rats alters the phenotype through a reduction in oxidative stress, thereby permitting endothelial cells to maintain an anti-apoptotic environment and the restoration of endothelial responses thus preventing hypertension.
Keywords: Heme oxygenase; hypertension; diabetes; adiponectin; oxidative stress; apoptosis

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MDPI and ACS Style

Cao, J.; Drummond, G.; Inoue, K.; Sodhi, K.; Li, X.Y.; Omura, S. Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress. Int. J. Mol. Sci. 2008, 9, 2388-2406.

AMA Style

Cao J, Drummond G, Inoue K, Sodhi K, Li XY, Omura S. Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress. International Journal of Molecular Sciences. 2008; 9(12):2388-2406.

Chicago/Turabian Style

Cao, Jian; Drummond, George; Inoue, Kazuyoshi; Sodhi, Komal; Li, Xiao Y.; Omura, Shinji. 2008. "Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress." Int. J. Mol. Sci. 9, no. 12: 2388-2406.

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