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Int. J. Mol. Sci. 2008, 9(10), 1977-1988; doi:10.3390/ijms9101977
Article

Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after Chronic Nonylphenol Exposure

1, 1,2, 2,* , 1,2, 2, 2 and 2
Received: 21 March 2008; in revised form: 9 October 2008 / Accepted: 13 October 2008 / Published: 24 October 2008
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: The present study was performed to investigate the effects of chronic administration of nonylphenol (NP) on the expression of inflammation-related genes in the brains of mice. NP was given orally by gavages at 0, 50, 100, and 200 mg/kg/d. The expression of inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), was evaluated by immunohistochemistry and immunoblotting assays. The nitric oxide (NO) level and nitric oxide synthase (NOS) activity were also measured by biochemical analyses. The results showed that NP at a high dose (200 mg/kg/d) significantly increased the expression of iNOS and COX-2 in both the hippocampus and cortex. In parallel with the increase in iNOS expression, the NO level was significantly greater at the dose of 200 mg/kg/d, compared to the control. The activity of NOS was also increased in the brain of mice at the dose of 100 and 200 mg/kg/d. These findings demonstrate that NP may have the potential to induce the chronic inflammation or cause neurotoxicity in the mouse brain.
Keywords: Nonylphenol; iNOS; COX-2; NO; brain Nonylphenol; iNOS; COX-2; NO; brain
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, Y.-Q.; Mao, Z.; Zheng, Y.-L.; Han, B.-P.; Chen, L.-T.; Li, J.; Li, F. Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after Chronic Nonylphenol Exposure. Int. J. Mol. Sci. 2008, 9, 1977-1988.

AMA Style

Zhang Y-Q, Mao Z, Zheng Y-L, Han B-P, Chen L-T, Li J, Li F. Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after Chronic Nonylphenol Exposure. International Journal of Molecular Sciences. 2008; 9(10):1977-1988.

Chicago/Turabian Style

Zhang, Yan-Qiu; Mao, Zhen; Zheng, Yuan-Lin; Han, Bao-Ping; Chen, Ling-Tong; Li, Jing; Li, Fei. 2008. "Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after Chronic Nonylphenol Exposure." Int. J. Mol. Sci. 9, no. 10: 1977-1988.



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