Int. J. Mol. Sci. 2004, 5(2), 37-47; doi:10.3390/i5020037
Article

Molecular Similarity of MDR Inhibitors

1,* email and 2
Received: 10 April 2003; Accepted: 31 August 2003 / Published: 30 January 2004
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of inhibitors of bacterial MDR were studied and there is a high similarity between these in terms of their shape, presence and orientation of aromatic ring moieties. A comparison of the lipophilic properties of these molecules has also been conducted suggesting that this factor is important in MDR inhibition.
Keywords: MDR; multidrug resistance; inhibitor; molecular similarity; SAR; ab initio
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MDPI and ACS Style

Zloh, M.; Gibbons, S. Molecular Similarity of MDR Inhibitors. Int. J. Mol. Sci. 2004, 5, 37-47.

AMA Style

Zloh M, Gibbons S. Molecular Similarity of MDR Inhibitors. International Journal of Molecular Sciences. 2004; 5(2):37-47.

Chicago/Turabian Style

Zloh, Mire; Gibbons, Simon. 2004. "Molecular Similarity of MDR Inhibitors." Int. J. Mol. Sci. 5, no. 2: 37-47.

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