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Int. J. Mol. Sci. 2003, 4(2), 34-44; doi:10.3390/i4020034

Effect of Turmeric, Turmerin and Curcumin on Ca2+, Na/K+ Atpases in Concanavalin A-Stimulated Human Blood Mononuclear Cells

Departments of Surgery and Medicine, University of Mississippi Medical Center, Jackson, MS, USA
Department of Biology, Alcorn State University, Lorman, MS, USA
Author to whom correspondence should be addressed.
Received: 7 June 2002 / Accepted: 30 October 2002 / Published: 31 January 2003
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Ion transport enzymes may play an important role in T cell activation. This study investigates the role of turmeric and its individual components, turmerin-and curcumin-on Ca2+ and Na/K+ adenosine triphosphatases (ATPase) in the course of T cell activation. Concanavalin A (Con A) stimulated human blood mononuclear T cell proliferation paradigm was investigated for 3, 5 and 7 day periods with different concentrations of turmeric, curcumin and turmerin. Con A-stimulated cells treated with turmeric (250, 50, 5 μg/ml) for 3 and 5 days inhibited ATPase levels when compared to base levels obtained by cells in media alone. At day 7, there was a 3-fold increase for Ca2+ATPase levels and a 2-fold increase for Na/K+ATPase. Curcumin (250, 50, 5 μg/ml) showed the same pattern for ATPase activity as turmeric at 3 and 5 days with a 2-fold increase at day 7. Turmerin (2500, 1250, 250, 25 ng/ml) for Na/K+ ATPase activity showed an increase at day 3, a decrease on day 5, and a 2-fold increase on day 7. Ca2+ ATPase activity in the presence of turmerin showed an increase in ATPase levels at day 3 (except at 2500ng/ml where it decreased) and a decrease in day 5 (except at 25 ng/ml where it increased). Turmeric and curcumin generally inhibited Ca2+ATPase and Na/K+ATPases in early (day 3) and intermediate (day 5) stages of mitogen stimulation. However, the effect after 7 days incubation for turmeric, curcumin and turmerin showed a marked increase up to three fold. View Full-Text
Keywords: Turmeric; turmerin; curcumin; Ca2+ATPase; Na/K+ATPase Turmeric; turmerin; curcumin; Ca2+ATPase; Na/K+ATPase

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MDPI and ACS Style

Cohly, H.H.P.; Rao, M.-R.; Kanji, V.K.; Patlolla, B.; Taylor, A.; Wilson, M.T.; Angel, M.F.; Das, S.K. Effect of Turmeric, Turmerin and Curcumin on Ca2+, Na/K+ Atpases in Concanavalin A-Stimulated Human Blood Mononuclear Cells. Int. J. Mol. Sci. 2003, 4, 34-44.

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