Photobiomodulation Therapy and the Glymphatic System: Promising Applications for Augmenting the Brain Lymphatic Drainage System
Round 1
Reviewer 1 Report
In the present manuscript, the authors report a complete description of the glymphatic system and its role in the brain lymphatic drainage system together with the principal results of the application of photobiomodulation therapy on animals, humans, and cells.
The manuscript is well-organized and clearly written and certainly deserves publication in the International Journal of Molecular Sciences.
However, in order to make this review more complete, I would suggest including a description of the most relevant experimental aspects (light sources and detectors characteristics, optical fibre systems adopted for sending light and collecting signal, data analysis procedures). This section could be also prepared as an Appendix or Supplementary material. Furthermore, since the description of the glymphatic system refers to the human one, it would be useful to give more emphasis to the results related to the application of PBM therapy on patients, even if the description of the results obtained on animal samples or cells is certainly useful for understanding the mechanisms. co-invests in the PBM and to indicate its potential.
Author Response
Dear Editor;
On behalf of my colleagues, I would like to express our utmost happiness to have your precious comments on our work which improved its quality a lot. Hereby, I present the responses to the reviewers’ comments on the manuscript entitled “Photobiomodulation Therapy and the Glymphatic System: Promising Applications for Augmenting the Brain Lymphatic Drainage System.”
REVIEWER 1
Comment 1:
Response 1: Thank you for your comment. The caption for the Figure 3 was changed accordingly.
Comment 2:
Response 2: It was added accordingly.
Comment 3:
Response 3: It was added accordingly.
Reviewer 2 Report
This manuscript, titled ‘Photobiomodulation therapy and the glymphatic system: promising applications for augmenting the brain lymphatic drainage system’ by Salehpour et al., reviewed the recent research efforts on elucidating the mechanisms of the glymphatic system which serves a crucial role in draining the brain wastes and developing the photobiomodulation (PBM) neuro-therapy for brain diseases associated with impaired brain glymphatic system. Overall, the manuscript flows clearly and makes a good summary, and after reading this manuscript, as a researcher not actively working on this particular area, I can quickly learn about this field advancement. So, the publication is recommended after a few minor revisions are addressed.
Minor revisions:
- Figure 3 caption notes only pathological conditions can affect the brain lymphatic system, but this figure content also includes other factors, so consider revising.
- In section 3.2, the last sentence of the fourth paragraph is incomplete.
- As a suggestion: because the authors reviewed both the role of brain lymphatic drainage system and PBM therapy, in the Conclusion, to better summarize what has been reviewed, I would recapitulate these two main parts first and then jump into the PBM discussion. Whereas, at present, the authors only talked about PBM therapy to conclude the review.
Author Response
REVIEWER 2
Comment 1:
Response 1: Please note that PBM therapy is a modulation technique which is based on delivering low levels of light in order to stimulate biological tissue. During the PBM procedure, no detector or signal collecting system is used. Thank you for your comment.
Comment 2:
Response 2: In the Conclusion section, the potential application for the human subjects was provided.
Sincerely Yours,
Dr. Joseph O. DiDuro
ProNeuroLIGHT LLC,
2030 W Baseline Rd
STE 182 PMB 6992
Phoenix, AZ 85041
E-mail: [email protected]
