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Article
Peer-Review Record

The Effect of Angiogenesis-Based Scaffold of MesoporousBioactive Glass Nanofiber on Osteogenesis

Int. J. Mol. Sci. 2022, 23(20), 12670; https://doi.org/10.3390/ijms232012670
by Weijia Zheng, Zhenzu Bai, Shan Huang, Kai Jiang, Long Liu * and Xiaoyan Wang *,†
Reviewer 1: Anonymous
Reviewer 2:
Int. J. Mol. Sci. 2022, 23(20), 12670; https://doi.org/10.3390/ijms232012670
Submission received: 26 September 2022 / Revised: 17 October 2022 / Accepted: 19 October 2022 / Published: 21 October 2022
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering 3.0)

Round 1

Reviewer 1 Report

Dear Authors, the comments and the questions ralated to the manuscript are provided in supplemented PDF file.

Comments for author File: Comments.pdf

Author Response

 

Author Response File: Author Response.docx

Reviewer 2 Report

The article “The effect of angiogenesis-based scaffold of Mesoporous bioactive glass nanofiber on osteogenesis” is devoted to development of novel bone scaffold that may heal critical-sized bone defects accelerating osteo- and angiogenesis. There are some issues that need to be considered:

Line 153 “To study the loading capacity of MBG-NH2, we tested the release ability for IGF-1.” Loading capacity and release are different parameters, and may not be connected directly (e.g., if loaded drug binds covalently to the material, or reveals strong adsorption forces). Loading capacity (LC%) is usually calculated by the amount of total entrapped drug divided by the total material weight.

It is suggested to provide a table with studied samples, their abbreviation and characterisation. This will improve readability.

Figure 1 C, D, E: the graphs are not readable; the fonts and scale should be increased.

Figure 4 F: scale bar is not readable.

For all Figures: the font size should be the same within the Figure.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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