p53 Controls Meiotic Prophase Progression and Crossover Formation
Abstract
:1. Introduction
2. Results
2.1. Testis Size in p53−/− Mutant Mice Is Not Altered
2.2. Prophase Progression Is Slightly Accelerated in the Absence of p53
2.3. CO Formation and Location Are Altered in p53 Absence
3. Discussion
4. Materials and Methods
4.1. Mutant Mice
4.2. Histology
4.3. Spermatocyte Spreads and Immunofluorescence
4.4. RNA Extraction and RT-qPCR
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Marcet-Ortega, M.; Maldonado-Linares, A.; López-Panadés, M.; Roig, I. p53 Controls Meiotic Prophase Progression and Crossover Formation. Int. J. Mol. Sci. 2022, 23, 9818. https://doi.org/10.3390/ijms23179818
Marcet-Ortega M, Maldonado-Linares A, López-Panadés M, Roig I. p53 Controls Meiotic Prophase Progression and Crossover Formation. International Journal of Molecular Sciences. 2022; 23(17):9818. https://doi.org/10.3390/ijms23179818
Chicago/Turabian StyleMarcet-Ortega, Marina, Andros Maldonado-Linares, Maria López-Panadés, and Ignasi Roig. 2022. "p53 Controls Meiotic Prophase Progression and Crossover Formation" International Journal of Molecular Sciences 23, no. 17: 9818. https://doi.org/10.3390/ijms23179818