Melatonin Levels in Preterm and Term Infants and Their Mothers
, Jean-François Benoist 7, Bruno Claustrat 8, Jérôme Barré 9, Marina Colella 10, Alice Frérot 10, Roselyne Garnotel 11, Olivier Graesslin 12, Bassam Haddad 13, Jean-Marie Launay 14, Thomas Schmitz 15, Julien Schroedt 16, Anne-Laure Virlouvet 10, Sophie Guilmin-Crépon 16, Adyla Yacoubi 16, Evelyne Jacqz-Aigrain 17, Pierre Gressens 2,3,18, add
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Round 1
Reviewer 1 Report
The presentation could be usefully strengthened by displaying error bars in Fig. 1, especially in panels A and C. It's important to know which percentages of pre- compared to normal-term infants are significantly different in these panels. However, given the limitation imposed by the 7 pg/ml experimental lower detection limit, normal error bars may or may not be meaningful, which is why this is not made a requirement for acceptance.
Reviewer 2 Report
The manuscript by Biran and colleagues titled "Melatonin levels in preterm and term infants and their mothers" brings new information regarding melatonin levels in preterm and term newborns, as well as, maternal milk. Prematurity remains the largest cause of neonatal mortality. there is an unmet need to provide more research and knowledge on how to prevent, or ameliorate such cases. Melatonin has been extensively studied and has shown some neuroprotective properties, and therefore any research that can shed more light into its potential beneficial role is important and needed.
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