Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation
Round 1
Reviewer 1 Report
Fumika Mi-ichi and Hiroki Yoshida has made a collection of their scientific production on the field of sulfur metabolism in amoeba and they writing this article, it has completed and include all the topics of their articles, completed with additional knowledge.
I only recommend change the word "ectopic" in in section 1.2 by other more adequate for describe the position of the liver in relation to the intestine and to the blood flow in which the amoeba is distributed to other organs from the intestine
Comments for author File: 
Comments.pdf
Author Response
Point-by-point responses to the specific comments of Reviewer 1.
We greatly appreciate Reviewer 1’s thorough review of our submitted manuscript and their candid and helpful comment.
Comment. I only recommend change the word “ectopic” in section 1.2 by other more adequate for describe the position of the liver in relation to the intestine and to the blood flow in which the amoeba is distributed to other organs from the intestine.
Our response. In accordance with Reviewer 1’s comment, we have changed the sentence in which the word “ectopic” is included in the revised version (Page 2 of the tracked copy).
Reviewer 2 Report
Honestly, I've not suggestions because I see a very understanding and well written manuscript.
The only question I have is regarding a possible comparison, at biochemical and genetic levels, of E. hystolitica parasite with E. dispar not pathogenic species, is feasible? this aspect should be discussed in the manuscript.
Author Response
Point-by-point responses to the specific comments of Reviewer 2.
We greatly appreciate Reviewer 2’s thorough review of our submitted manuscript and their candid and helpful comment.
Comment. The only question I have is regarding a possible comparison, at biochemical and genetic levels, of E. histolytica parasite with E. dispar not pathogenic species, is feasible? this aspect should be discussed in the manuscript.
Our response. In accordance with Reviewer 2’s comment, we have added the discussion on the raised issue in the revised version (Page 7 of the tracked copy).
