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Int. J. Mol. Sci. 2018, 19(8), 2299; https://doi.org/10.3390/ijms19082299

Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

1
Department of Infectious Disease, Infection Control and Employee Health, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2
Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Received: 13 June 2018 / Revised: 13 July 2018 / Accepted: 2 August 2018 / Published: 5 August 2018
(This article belongs to the Special Issue Advances in Biological Functions of STAT3)
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Abstract

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need. View Full-Text
Keywords: STAT3; asthma; inflammatory bowel disease (IBD); ulcerative colitis (UC); Crohn’s disease (CD); fibrosis; cachexia STAT3; asthma; inflammatory bowel disease (IBD); ulcerative colitis (UC); Crohn’s disease (CD); fibrosis; cachexia
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Kasembeli, M.M.; Bharadwaj, U.; Robinson, P.; Tweardy, D.J. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int. J. Mol. Sci. 2018, 19, 2299.

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