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Int. J. Mol. Sci. 2018, 19(6), 1721; https://doi.org/10.3390/ijms19061721

Potential Clinical Application of Genomics in Multiple Myeloma

1
Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, 1E Kent Ridge Road, Singapore 119228, Singapore
2
Department of Laboratory Medicine, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
3
Cancer Science Institute of Singapore, National University of Singapore,14 Medical Drive, Singapore 117599, Singapore
*
Author to whom correspondence should be addressed.
Received: 14 May 2018 / Revised: 2 June 2018 / Accepted: 7 June 2018 / Published: 10 June 2018
View Full-Text   |   Download PDF [266 KB, uploaded 10 June 2018]

Abstract

Multiple myeloma is a heterogeneous disease with different characteristics, and genetic aberrations play important roles in this heterogeneity. Studies have shown that these genetic aberrations are crucial in prognostication and response assessment; recent efforts have focused on their possible therapeutic implications. Despite many emerging studies being published, the best way to incorporate these results into clinical practice remains unclear. In this review paper we describe the different genomic techniques available, including the latest advancements, and discuss the potential clinical application of genomics in multiple myeloma. View Full-Text
Keywords: multiple myeloma; genomics; gene expression profiling multiple myeloma; genomics; gene expression profiling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Soekojo, C.Y.; de Mel, S.; Ooi, M.; Yan, B.; Chng, W.J. Potential Clinical Application of Genomics in Multiple Myeloma. Int. J. Mol. Sci. 2018, 19, 1721.

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