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Int. J. Mol. Sci. 2018, 19(6), 1706; https://doi.org/10.3390/ijms19061706

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis

1
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
2
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore
3
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore
*
Author to whom correspondence should be addressed.
Received: 17 May 2018 / Revised: 4 June 2018 / Accepted: 4 June 2018 / Published: 8 June 2018
(This article belongs to the Special Issue Human Polyomaviruses and Papillomaviruses)
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Abstract

Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression. The most well-studied cellular targets of the viral oncogenes E6 and E7 are p53 and pRb, respectively. However, recent research has demonstrated the ability of these two viral factors to target many more cellular factors, including proteins which regulate epigenetic marks and splicing changes in the cell. These have the ability to exert a global change, which eventually culminates to uncontrolled proliferation and carcinogenesis. View Full-Text
Keywords: HPV; human papillomavirus; cervical cancer; viral oncogenes; E6; E7; viral-induced cancers HPV; human papillomavirus; cervical cancer; viral oncogenes; E6; E7; viral-induced cancers
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Yeo-Teh, N.S.L.; Ito, Y.; Jha, S. High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis. Int. J. Mol. Sci. 2018, 19, 1706.

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