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Int. J. Mol. Sci. 2018, 19(6), 1641; https://doi.org/10.3390/ijms19061641

Biomimetic Layer-by-Layer Self-Assembly of Nanofilms, Nanocoatings, and 3D Scaffolds for Tissue Engineering

1
Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
2
Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
3
The Children’s Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada
4
West Virginia University Cancer Institute, Morgantown, WV 26506, USA
*
Author to whom correspondence should be addressed.
Received: 25 April 2018 / Revised: 29 May 2018 / Accepted: 30 May 2018 / Published: 1 June 2018
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2018)
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Abstract

Achieving surface design and control of biomaterial scaffolds with nanometer- or micrometer-scaled functional films is critical to mimic the unique features of native extracellular matrices, which has significant technological implications for tissue engineering including cell-seeded scaffolds, microbioreactors, cell assembly, tissue regeneration, etc. Compared with other techniques available for surface design, layer-by-layer (LbL) self-assembly technology has attracted extensive attention because of its integrated features of simplicity, versatility, and nanoscale control. Here we present a brief overview of current state-of-the-art research related to the LbL self-assembly technique and its assembled biomaterials as scaffolds for tissue engineering. An overview of the LbL self-assembly technique, with a focus on issues associated with distinct routes and driving forces of self-assembly, is described briefly. Then, we highlight the controllable fabrication, properties, and applications of LbL self-assembly biomaterials in the forms of multilayer nanofilms, scaffold nanocoatings, and three-dimensional scaffolds to systematically demonstrate advances in LbL self-assembly in the field of tissue engineering. LbL self-assembly not only provides advances for molecular deposition but also opens avenues for the design and development of innovative biomaterials for tissue engineering. View Full-Text
Keywords: layer-by-layer; self-assembly; polyelectrolyte; multilayer; nanofilm; nanocoating; biomaterial; scaffold; tissue engineering layer-by-layer; self-assembly; polyelectrolyte; multilayer; nanofilm; nanocoating; biomaterial; scaffold; tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Zhang, S.; Xing, M.; Li, B. Biomimetic Layer-by-Layer Self-Assembly of Nanofilms, Nanocoatings, and 3D Scaffolds for Tissue Engineering. Int. J. Mol. Sci. 2018, 19, 1641.

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