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Int. J. Mol. Sci. 2018, 19(4), 928; doi:10.3390/ijms19040928

Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle

1
Department of Sciences and Technologies, University of Sannio, 82100 Benevento, Italy
2
CEINGE Biotecnologie Avanzate s.c.ar.l., 80145 Naples, Italy
3
Department of Pediatric Oncology and Hematology, Charité University Hospital, 13353 Berlin, Germany
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 18 February 2018 / Revised: 14 March 2018 / Accepted: 20 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Sirtuins and Epigenetics in Aging and Diseases)
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Abstract

Fighting diseases and controlling the signs of ageing are the major goals of biomedicine. Sirtuins, enzymes with mainly deacetylating activity, could be pivotal targets of novel preventive and therapeutic strategies to reach such aims. Scientific proofs are accumulating in experimental models, but, to a minor extent, also in humans, that the ancient practice of calorie restriction could prove an effective way to prevent several degenerative diseases and to postpone the detrimental signs of ageing. In the present review, we summarize the evidence about the central role of sirtuins in mediating the beneficial effects of calorie restriction in skeletal and cardiac muscle since these tissues are greatly damaged by diseases and advancing years. Moreover, we entertain the possibility that the identification of sirtuin activators that mimic calorie restriction could provide the benefits without the inconvenience of this dietary style. View Full-Text
Keywords: sirtuins; calorie restriction; ageing; nutrient deprivation; skeletal muscle; cardiac muscle sirtuins; calorie restriction; ageing; nutrient deprivation; skeletal muscle; cardiac muscle
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Zullo, A.; Simone, E.; Grimaldi, M.; Musto, V.; Mancini, F.P. Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle. Int. J. Mol. Sci. 2018, 19, 928.

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