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Int. J. Mol. Sci. 2018, 19(4), 1246; https://doi.org/10.3390/ijms19041246

Human Cancer and Platelet Interaction, a Potential Therapeutic Target

1
,
2
and
1,3,*
1
Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
2
Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536, USA
3
Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
*
Author to whom correspondence should be addressed.
Received: 2 March 2018 / Revised: 30 March 2018 / Accepted: 16 April 2018 / Published: 20 April 2018
(This article belongs to the Special Issue Extracellular Matrix in Development and Disease)
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Abstract

Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer development and progression are associated with platelet activation. Xenograft experiments and transgenic mouse models further demonstrate that platelet activation and platelet-cancer cell interaction are crucial for cancer metastasis. Direct or indirect interaction of platelets induces cancer cell plasticity and enhances survival and extravasation of circulating cancer cells during dissemination. In vivo and in vitro experiments also demonstrate that cancer cells induce platelet aggregation, suggesting that platelet-cancer interaction is bidirectional. Therefore, understanding how platelets crosstalk with cancer cells may identify potential strategies to inhibit cancer metastasis and to reduce cancer-related thrombosis. Here, we discuss the potential function of platelets in regulating cancer progression and summarize the factors and signaling pathways that mediate the cancer cell-platelet interaction. View Full-Text
Keywords: cancer metastasis; platelet; biomarker; cancer therapy cancer metastasis; platelet; biomarker; cancer therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, S.; Li, Z.; Xu, R. Human Cancer and Platelet Interaction, a Potential Therapeutic Target. Int. J. Mol. Sci. 2018, 19, 1246.

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