DDX5 RNA Helicases: Emerging Roles in Viral Infection
Abstract
:1. Introduction
2. Modular Domain Structure of DDX5
3. DDX5 Is a Host Factor Influencing Viral Infection
3.1. DDX5 Interacts with Severe Acute Respiratory Syndrome Coronavirus Helicase
3.2. DDX5 Facilitates Human Immunodeficiency Virus 1 mRNA Export
3.3. DDX5 Is Involved in the Hepatitis C Virus (HCV) Life Cycle
3.4. DDX5 Acts as a Positive Regulator of Japanese Encephalitis Virus Replication
3.5. DDX5 Positively Regulates the Replication of Porcine Reproductive and Respiratory Syndrome Virus
3.6. DDX5 Enhances the Polymerase Activity of Influenza Virus
3.7. DDX5 Interacts with EBNA2 of Epstein-Barr Virus
3.8. DDX5 Restricts Myxoma Virus Replication and HBV Transcription
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Virus | Viral Binding Protein | Effect of DDX5 on Viral Replication | Ref. |
---|---|---|---|
SARS-CoV | nsp13 | Enhances virus proliferation | [16] |
IBV-CoV | nsp13 | Enhances virus proliferation | [16] |
HIV-1 | Rev | Enhances the Rev-dependent RNA export | [17] |
HCV | NS5B | Required for transcription of viral RNA | [18] |
JEV | C, NS3 and NS5 | Required for viral RNA replication | [19] |
PRRSV | nsp9 | Required for viral replication | [20] |
Influenza virus | NP | Required for viral replication | [21] |
EBV | EBNA2 | Unknown | [24] |
Pestivirus | Npro | Unknown | [25] |
Myxoma virus | Unknown | Inhibits viral replication | [22] |
HBV | Unknown | Inhibits viral replication | [23] |
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Cheng, W.; Chen, G.; Jia, H.; He, X.; Jing, Z. DDX5 RNA Helicases: Emerging Roles in Viral Infection. Int. J. Mol. Sci. 2018, 19, 1122. https://doi.org/10.3390/ijms19041122
Cheng W, Chen G, Jia H, He X, Jing Z. DDX5 RNA Helicases: Emerging Roles in Viral Infection. International Journal of Molecular Sciences. 2018; 19(4):1122. https://doi.org/10.3390/ijms19041122
Chicago/Turabian StyleCheng, Wenyu, Guohua Chen, Huaijie Jia, Xiaobing He, and Zhizhong Jing. 2018. "DDX5 RNA Helicases: Emerging Roles in Viral Infection" International Journal of Molecular Sciences 19, no. 4: 1122. https://doi.org/10.3390/ijms19041122