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Int. J. Mol. Sci. 2018, 19(2), 460; https://doi.org/10.3390/ijms19020460

MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia

1
Laboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture, Italy
2
Biogem Scarl, Istituto di Ricerche Genetiche ‘Gaetano Salvatore’, 83031 Ariano Irpino, Italy
3
Department of Biology, University of Naples Federico II, 80147 Naples, Italy
4
CEINGE Biotecnologie Avanzate s.c.a r.l., 80147 Naples, Italy
5
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80138 Naples, Italy
6
Scientific Direction, IRCCS—Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture, Potenza, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 12 January 2018 / Accepted: 12 January 2018 / Published: 3 February 2018
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Abstract

Acute myeloid leukemias (AML) are clonal disorders of hematopoietic progenitor cells which are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical features. Among the genetic aberrations that control disease development there are microRNAs (miRNAs). miRNAs are small non-coding RNAs that regulate, at post-transcriptional level, translation and stability of mRNAs. It is now established that deregulated miRNA expression is a prominent feature in AML. Functional studies have shown that miRNAs play an important role in AML pathogenesis and miRNA expression signatures are associated with chemotherapy response and clinical outcome. In this review we summarized miRNA signature in AML with different cytogenetic, molecular and clinical characteristics. Moreover, we reviewed the miRNA regulatory network in AML pathogenesis and we discussed the potential use of cellular and circulating miRNAs as biomarkers for diagnosis and prognosis and as therapeutic targets. View Full-Text
Keywords: microRNAs; acute myeloid leukemia; biomarkers; therapeutic targets microRNAs; acute myeloid leukemia; biomarkers; therapeutic targets
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Trino, S.; Lamorte, D.; Caivano, A.; Laurenzana, I.; Tagliaferri, D.; Falco, G.; Del Vecchio, L.; Musto, P.; De Luca, L. MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia. Int. J. Mol. Sci. 2018, 19, 460.

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