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Int. J. Mol. Sci. 2018, 19(2), 430; https://doi.org/10.3390/ijms19020430

Role of Galectins in Tumors and in Clinical Immunotherapy

1
Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 114, Taiwan
2
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
3
Teaching and Research Office, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei 105, Taiwan
*
Author to whom correspondence should be addressed.
Received: 30 December 2017 / Revised: 25 January 2018 / Accepted: 30 January 2018 / Published: 1 February 2018
(This article belongs to the Special Issue Galectins in Cancer and Translational Medicine)
View Full-Text   |   Download PDF [242 KB, uploaded 1 February 2018]   |  

Abstract

Galectins are glycan-binding proteins that contain one or two carbohydrate domains and mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal expression of galectins is known to be linked to the development, progression and metastasis of cancers. Galectins also have diverse functions on different immune cells that either promote inflammation or dampen T cell-mediated immune responses, depending on cognate receptors on target cells. Thus, tumor-derived galectins can have bifunctional effects on tumor and immune cells. This review focuses on the biological effects of galectin-1, galectin-3 and galectin-9 in various cancers and discusses anticancer therapies that target these molecules. View Full-Text
Keywords: galectin-1; galectin-3; galectin-9; immunotherapy; galectin inhibitors galectin-1; galectin-3; galectin-9; immunotherapy; galectin inhibitors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chou, F.-C.; Chen, H.-Y.; Kuo, C.-C.; Sytwu, H.-K. Role of Galectins in Tumors and in Clinical Immunotherapy. Int. J. Mol. Sci. 2018, 19, 430.

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