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Int. J. Mol. Sci. 2018, 19(2), 377; doi:10.3390/ijms19020377

Autoimmunity and Gastric Cancer

Laboratorio di Patologia Clinica, Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy
Laboratorio Analisi ULSS 4, 36014 Santorso, Italy
Immunologia e Allergologia, Presidio Ospedaliero S. Maria degli Angeli, 33170 Pordenone, Italy
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 23 January 2018 / Accepted: 24 January 2018 / Published: 26 January 2018
(This article belongs to the Special Issue Molecular Features Distinguishing Gastric Cancer Subtypes)
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Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms. View Full-Text
Keywords: autoimmune diseases; autoimmune gastritis; gastric cancer; Helicobacter pylori infection; intrinsic factor antibodies; parietal cell antibodies autoimmune diseases; autoimmune gastritis; gastric cancer; Helicobacter pylori infection; intrinsic factor antibodies; parietal cell antibodies

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bizzaro, N.; Antico, A.; Villalta, D. Autoimmunity and Gastric Cancer. Int. J. Mol. Sci. 2018, 19, 377.

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