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Int. J. Mol. Sci. 2018, 19(2), 377; doi:10.3390/ijms19020377

Autoimmunity and Gastric Cancer

1
Laboratorio di Patologia Clinica, Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy
2
Laboratorio Analisi ULSS 4, 36014 Santorso, Italy
3
Immunologia e Allergologia, Presidio Ospedaliero S. Maria degli Angeli, 33170 Pordenone, Italy
*
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 23 January 2018 / Accepted: 24 January 2018 / Published: 26 January 2018
(This article belongs to the Special Issue Molecular Features Distinguishing Gastric Cancer Subtypes)
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Abstract

Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms. View Full-Text
Keywords: autoimmune diseases; autoimmune gastritis; gastric cancer; Helicobacter pylori infection; intrinsic factor antibodies; parietal cell antibodies autoimmune diseases; autoimmune gastritis; gastric cancer; Helicobacter pylori infection; intrinsic factor antibodies; parietal cell antibodies
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Bizzaro, N.; Antico, A.; Villalta, D. Autoimmunity and Gastric Cancer. Int. J. Mol. Sci. 2018, 19, 377.

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