The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation
AbstractTriptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been shown to exert potent pharmacological effects, especially an immunosuppressive effect in the treatment of rheumatoid arthritis (RA). However, its multiorgan toxicity prevents it from being widely used in clinical practice. Recently, several attempts are being performed to reduce TP toxicity. In this review, recent progress in the use of TP for RA, including its pharmacological effects and toxicity, is summarized. Meanwhile, strategies relying on chemical structural modifications, innovative delivery systems, and drug combinations to alleviate the disadvantages of TP are also reviewed. Furthermore, we also discuss the challenges and perspectives in their clinical translation. View Full-Text
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Fan, D.; Guo, Q.; Shen, J.; Zheng, K.; Lu, C.; Zhang, G.; Lu, A.; He, X. The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation. Int. J. Mol. Sci. 2018, 19, 376.
Fan D, Guo Q, Shen J, Zheng K, Lu C, Zhang G, Lu A, He X. The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation. International Journal of Molecular Sciences. 2018; 19(2):376.Chicago/Turabian Style
Fan, Danping; Guo, Qingqing; Shen, Jiawen; Zheng, Kang; Lu, Cheng; Zhang, Ge; Lu, Aiping; He, Xiaojuan. 2018. "The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation." Int. J. Mol. Sci. 19, no. 2: 376.
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