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Int. J. Mol. Sci. 2018, 19(2), 356; https://doi.org/10.3390/ijms19020356

Present Status and Future Challenges of New Therapeutic Targets in Preclinical Models of Stroke in Aged Animals with/without Comorbidities

1
Griffith University School of Medicine, Gold Coast Campus, QLD, Queensland Eye Institute, Brisbane, QLD 4101, Australia
2
Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Psychiatry Clinic Hospital, University of Medicine and Pharmacy of Craiova, Petru Rares Street 2, 200349 Craiova, Romania
4
Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
5
Medlife Clinic, Department of Ophthalmology, 200349 Craiova, Romania
6
Department of Neurosurgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
7
Department of “Mother and Child”, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 27 December 2017 / Revised: 18 January 2018 / Accepted: 22 January 2018 / Published: 25 January 2018
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Abstract

The aging process, comorbidities, and age-associated diseases are closely dependent on each other. Cerebral ischemia impacts a wide range of systems in an age-dependent manner. However, the aging process has many facets which are influenced by the genetic background and epigenetic or environmental factors, which can explain why some people age differently than others. Therefore, there is an urgent need to identify age-related changes in body functions or structures that increase the risk for stroke and which are associated with a poor outcome. Multimodal imaging, electrophysiology, cell biology, proteomics, and transcriptomics, offer a useful approach to link structural and functional changes in the aging brain, with or without comorbidities, to post-stroke rehabilitation. This can help us to improve our knowledge about senescence firstly, and in this context, aids in elucidating the pathophysiology of age-related diseases that allows us to develop therapeutic strategies or prevent diseases. These processes, including potential therapeutical interventions, need to be studied first in relevant preclinical models using aged animals, with and without comorbidities. Therefore, preclinical research on ischemic stroke should consider age as the most important risk factor for cerebral ischemia. Furthermore, the identification of effective therapeutic strategies, corroborated with successful translational studies, will have a dramatic impact on the lives of millions of people with cerebrovascular diseases. View Full-Text
Keywords: aging; stroke; regeneration; rehabilitation; therapy; animal models aging; stroke; regeneration; rehabilitation; therapy; animal models
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Popa-Wagner, A.; Glavan, D.-G.; Olaru, A.; Olaru, D.-G.; Margaritescu, O.; Tica, O.; Surugiu, R.; Sandu, R.E. Present Status and Future Challenges of New Therapeutic Targets in Preclinical Models of Stroke in Aged Animals with/without Comorbidities. Int. J. Mol. Sci. 2018, 19, 356.

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