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Int. J. Mol. Sci. 2018, 19(2), 347; doi:10.3390/ijms19020347

Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story

1
Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands
2
LifeGlimmer GmbH, Markelstrasse 38, 12163 Berlin, Germany
*
Author to whom correspondence should be addressed.
Received: 28 December 2017 / Revised: 19 January 2018 / Accepted: 21 January 2018 / Published: 24 January 2018
(This article belongs to the Special Issue Molecular Mechanism of Infectious Disease)
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Abstract

Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly challenging. In order to develop novel intervention strategies, detailed understanding of the molecular mechanisms behind the success of this pathogen is required. Here, we review recent literature to provide a systems level overview of the molecular and cellular components involved in divalent metal homeostasis and their role in regulating the three main virulence strategies of M. tuberculosis: immune modulation, dormancy and phagosomal rupture. We provide a visual and modular overview of these components and their regulation. Our analysis identified a single regulatory cascade for these three virulence strategies that respond to limited availability of divalent metals in the phagosome. View Full-Text
Keywords: Mycobacteria; virulence; immune modulation; dormancy; escape; phagosome rupture; divalent metal; pore; cAMP; manganese; iron; zinc; esx Mycobacteria; virulence; immune modulation; dormancy; escape; phagosome rupture; divalent metal; pore; cAMP; manganese; iron; zinc; esx
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zondervan, N.A.; van Dam, J.C.J.; Schaap, P.J.; Martins dos Santos, V.A.P.; Suarez-Diez, M. Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story. Int. J. Mol. Sci. 2018, 19, 347.

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