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Int. J. Mol. Sci. 2018, 19(2), 338; https://doi.org/10.3390/ijms19020338

The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients

1
Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila Street 19, 50411 Tartu, Estonia
2
Competence Centre on Health Technologies, Tiigi Street 61B, 50410 Tartu, Estonia
3
Abdominal Surgery Department of Tartu University Hospital, Puusepa Street 8, 51014 Tartu, Estonia
*
Author to whom correspondence should be addressed.
Received: 12 December 2017 / Revised: 9 January 2018 / Accepted: 18 January 2018 / Published: 24 January 2018
(This article belongs to the Special Issue Helicobacter pylori Research)
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Abstract

Helicobacter pylori (Hp) is one of the most important human pathogens that can cause duodenal and gastric ulcers, gastritis and stomach cancer. Hp infection is considered to be a cause of limiting access to bariatric surgery. The aim of this study was to determine the prevalence of Hp in patients with obesity going into bariatric surgery and to reveal the relationship between Hp and clinical data. The study group was formed of 68 preoperative bariatric surgery patients (body mass index (BMI) 44.7 ± 4.8). Gastric biopsies (antrum and corpus) were used for histological and molecular (caqA and glmM genes) examinations. The PCR method revealed Hp infection in 64.7% of obese patients that is higher in comparison with histological analysis (55.9%). The prevalence of cagA and glmM genes in antrum mucosa was 45.6% and 47.0% while in the corpus it was 41.2% and 38.3%, respectively. The coincidence of both cagA and glmM virulence genes in the antrum and corpus mucosa was 33.8% and 22.1%, respectively. Either of the genes was found in 58.8% of antrum and 57.3% of corpus mucosa. Presence of caqA and glmM genes was in association with active and atrophic chronic gastritis. In conclusion, our study demonstrated that two thirds of morbidly obese patients undergoing bariatric surgery are infected with Hp and have a high prevalence of cagA and glmM virulence genes that points out the necessity for diagnostics and treatment of this infection before surgery. View Full-Text
Keywords: Helicobacter pylori; glmM gene; cagA gene; PCR; gastritis; obesity; virulence factors Helicobacter pylori; glmM gene; cagA gene; PCR; gastritis; obesity; virulence factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Šebunova, N.; Štšepetova, J.; Sillakivi, T.; Mändar, R. The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients. Int. J. Mol. Sci. 2018, 19, 338.

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