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Int. J. Mol. Sci. 2018, 19(3), 708; https://doi.org/10.3390/ijms19030708

Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study

1
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu-City, Oita 879-5593, Japan
2
Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam
3
Department of Endoscopy, Daklak Hospital, Daklak, Vietnam
4
Department of Endoscopy, Lao Cai Hospital, Lao Cai, Vietnam
5
Department of Endoscopy, Bach Mai Hospital, Hanoi, Vietnam
6
Department of Molecular Biology, 108 Military Central Hospital, Hanoi, Vietnam
7
Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan
8
Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Vietnam
9
Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX 77030, USA
These authors contributed equally to this work
*
Author to whom correspondence should be addressed.
Received: 29 January 2018 / Revised: 25 February 2018 / Accepted: 27 February 2018 / Published: 1 March 2018
(This article belongs to the Special Issue Helicobacter pylori Research)
Full-Text   |   PDF [927 KB, uploaded 1 March 2018]   |  

Abstract

The Helicobacter pylori-induced burden of gastric cancer varies based on geographical regions and ethnic grouping. Vietnam is a multiethnic country with the highest incidence of gastric cancer in Southeast Asia, but previous studies focused only on the Kinh ethnic group. A population-based cross-sectional study was conducted using 494 volunteers (18–78 years old), from 13 ethnic groups in Daklak and Lao Cai provinces, Vietnam. H. pylori status was determined by multiple tests (rapid urease test, culture, histology, and serology). cagA and vacA genotypes were determined by PCR-based sequencing. The overall H. pylori infection rate was 38.1%. Multivariate analysis showed that variations in geographical region, age, and ethnicity were independent factors associated with the risk of H. pylori acquisition. Therefore, multicenter, multiethnic, population based study is essential to assess the H. pylori prevalence and its burden in the general population. Only the E De ethnicity carried strains with Western-type CagA (82%) and exhibited significantly lower gastric mucosal inflammation compared to other ethnic groups. However, the histological scores of Western-type CagA and East-Asian-type CagA within the E De group showed no significant differences. Thus, in addition to bacterial virulence factors, host factors are likely to be important determinants for gastric mucosal inflammation and contribute to the Asian enigma. View Full-Text
Keywords: Helicobacter pylori; molecular epidemiology; virulence factor; Asian enigma Helicobacter pylori; molecular epidemiology; virulence factor; Asian enigma
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Binh, T.T.; Tuan, V.P.; Dung, H.D.Q.; Tung, P.H.; Tri, T.D.; Thuan, N.P.M.; Tam, L.Q.; Nam, B.C.; Giang, D.A.; Hoan, P.Q.; Uchida, T.; Trang, T.T.H.; Khien, V.V.; Yamaoka, Y. Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study. Int. J. Mol. Sci. 2018, 19, 708.

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