Next Article in Journal
Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein
Next Article in Special Issue
Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
Previous Article in Journal
Visualization and Quantitative 3D Analysis of Intraocular Melanoma and Its Vascularization in a Hamster Eye
Previous Article in Special Issue
Telomeres: Implications for Cancer Development
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(2), 333; https://doi.org/10.3390/ijms19020333

Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites

Department of Biological Sciences, The University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
*
Author to whom correspondence should be addressed.
Received: 20 December 2017 / Revised: 10 January 2018 / Accepted: 17 January 2018 / Published: 24 January 2018
(This article belongs to the Special Issue Role of Telomeres and Telomerase in Cancer and Aging)
View Full-Text   |   Download PDF [5965 KB, uploaded 24 January 2018]   |  

Abstract

Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant lengthening or reduction in the length of telomeres can lead to health anomalies, such as cancer or premature aging. Telomerase is a master regulator for maintaining replicative potential in most eukaryotic cells. It does so by controlling telomere length at chromosome ends. Akin to cancer cells, most single-cell eukaryotic pathogens are highly proliferative and require persistent telomerase activity to maintain constant length of telomere and propagation within their host. Although telomerase is key to unlimited cellular proliferation in both cases, not much was known about the role of telomerase in human parasites (malaria, Trypanosoma, etc.) until recently. Since telomerase regulation is mediated via its own structural components, interactions with catalytic reverse transcriptase and several factors that can recruit and assemble telomerase to telomeres in a cell cycle-dependent manner, we compare and discuss here recent findings in telomerase biology in cancer, aging and parasitic diseases to give a broader perspective of telomerase function in human diseases. View Full-Text
Keywords: telomerase; telomere; TER; TERT; parasite; Trypanosoma brucei; Plasmodium falciparum; RNA; RNP; DNA repair; cellular senescence; cancer; ageing telomerase; telomere; TER; TERT; parasite; Trypanosoma brucei; Plasmodium falciparum; RNA; RNP; DNA repair; cellular senescence; cancer; ageing
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Dey, A.; Chakrabarti, K. Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites. Int. J. Mol. Sci. 2018, 19, 333.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top