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Int. J. Mol. Sci. 2018, 19(1), 99; doi:10.3390/ijms19010099

Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects

1
Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania
2
Gold Coast Campus, School of Medicine, Griffith University, Southport 4222, Australia
*
Author to whom correspondence should be addressed.
Received: 14 November 2017 / Revised: 22 December 2017 / Accepted: 24 December 2017 / Published: 29 December 2017
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Abstract

The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia. Indeed, recent results suggest that H2S-induced hypothermia in aged, overweight rats could have a higher probability of success in treating stroke as compared to other monotherapies, by reducing post-stroke brain inflammation. Likewise, it was recently reported that weight reduction prior to stroke, in aged, overweight rats induced by caloric restriction, led to an early re-gain of weight and a significant improvement in recovery of complex sensorimotor skills, cutaneous sensitivity, or spatial memory. Conclusion: animal models of stroke done in young animals ignore age-associated comorbidities and may explain, at least in part, the unsuccessful bench-to-bedside translation of neuroprotective strategies for ischemic stroke in aged subjects. View Full-Text
Keywords: ageing; cerebral ischemia; obesity; inflammation; hypothermia; calorie restriction ageing; cerebral ischemia; obesity; inflammation; hypothermia; calorie restriction
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Sandu, R.E.; Dumbrava, D.; Surugiu, R.; Glavan, D.-G.; Gresita, A.; Petcu, E.B. Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects. Int. J. Mol. Sci. 2018, 19, 99.

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