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Int. J. Mol. Sci. 2018, 19(1), 284; doi:10.3390/ijms19010284

Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia/Reperfusion

1
Department of Surgery, Instituto Português de Oncologia de Coimbra, 3000-075 Coimbra, Portugal
2
Department of Life Sciences, Faculty of Sciences and Technology, and Center of Neurosciences and Cell Biology, University of Coimbra, 3004-531 Coimbra, Portugal
3
Department of Transplantação Hepática de Crianças e Adultos, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
4
Department of Pathology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
5
Department of Surgery A, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
6
Clínica Universitária de Cirurgia III, Faculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal
7
Center for Investigation on Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
Received: 5 December 2017 / Revised: 12 January 2018 / Accepted: 14 January 2018 / Published: 19 January 2018
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Abstract

Liver transplantation is a therapeutic regimen to treat patients with non-malignant end-stage liver diseases and malignant tumors of hepatic origin. The ischemia/reperfusion (I/R) injury in liver transplantation is associated with disruption of mitochondrial function in the hepatic parenchyma. Several studies have been conducted in animal models to identify pharmacological therapeutic strategies to minimize the injury induced by the cold/warm I/R in liver transplantation. Most of these studies were conducted in unrealistic conditions without the potential to be translated to clinical usage. Berberine (BBR) is a pharmacological compound with a potential protective effect of the mitochondrial function in the context of I/R. For the future clinical application of these pharmacological strategies, it is essential that a close resemblance exists between the methodology used in the animals models and real life. In this study, we have demonstrated that the addition of BBR to the preservation solution in an I/R setting preserves mitochondrial function and bioenergetics, protecting the liver from the deleterious effects caused by I/R. As such, BBR has the potential to be used as a pharmacological therapeutic strategy. View Full-Text
Keywords: liver transplantation; berberine; ischemia/reperfusion injury liver transplantation; berberine; ischemia/reperfusion injury
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Martins, R.M.; Pinto Rolo, A.; Soeiro Teodoro, J.; Furtado, E.; Caetano Oliveira, R.; Tralhão, J.G.; Marques Palmeira, C. Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia/Reperfusion. Int. J. Mol. Sci. 2018, 19, 284.

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