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Int. J. Mol. Sci. 2018, 19(1), 278; doi:10.3390/ijms19010278

The Root of Atractylodes macrocephala Koidzumi Prevents Obesity and Glucose Intolerance and Increases Energy Metabolism in Mice

1
Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University, Dongdaero 123, Gyeongju-si 38066, Korea
2
Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University, Donggukro 27, Ilsandong-gu, Goyang-si 10326, Korea
*
Author to whom correspondence should be addressed.
Received: 5 December 2017 / Revised: 9 January 2018 / Accepted: 10 January 2018 / Published: 17 January 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Targeting energy expenditure offers a strategy for treating obesity more effectively and safely. In previous studies, we found that the root of Atractylodes macrocephala Koidzumi (Atractylodis Rhizoma Alba, ARA) increased energy metabolism in C2C12 cells. Here, we investigated the effects of ARA on obesity and glucose intolerance by examining energy metabolism in skeletal muscle and brown fat in high-fat diet (HFD) induced obese mice. ARA decreased body weight gain, hepatic lipid levels and serum total cholesterol levels, but did not modify food intake. Fasting serum glucose, serum insulin levels and glucose intolerance were all improved in ARA treated mice. Furthermore, ARA increased peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) expression, and the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle tissues, and also prevented skeletal muscle atrophy. In addition, the numbers of brown adipocytes and the expressions of PGC1α and uncoupling protein 1 (UCP1) were elevated in the brown adipose tissues of ARA treated mice. Our results show that ARA can prevent diet-induced obesity and glucose intolerance in C5BL/6 mice and suggests that the mechanism responsible is related to the promotion of energy metabolism in skeletal muscle and brown adipose tissues. View Full-Text
Keywords: Atractylodis Rhizoma Alba; obesity; glucose intolerance; skeletal muscle; brown fat; energy metabolism Atractylodis Rhizoma Alba; obesity; glucose intolerance; skeletal muscle; brown fat; energy metabolism
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MDPI and ACS Style

Song, M.Y.; Lim, S.-K.; Wang, J.-H.; Kim, H. The Root of Atractylodes macrocephala Koidzumi Prevents Obesity and Glucose Intolerance and Increases Energy Metabolism in Mice. Int. J. Mol. Sci. 2018, 19, 278.

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