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Int. J. Mol. Sci. 2018, 19(1), 260; doi:10.3390/ijms19010260

Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis

1
Department of Public Health and Clinical Medicine, Umeå University, 901 87 Umeå, Sweden
2
Cardiology Department, Letterkenny University Hospital, Letterkenny, F92 AE81, Co. Donegal, Ireland
3
Molecular Periodontology and Odontology, Umeå University, 901 87 Umeå, Sweden
4
Department of Radiation Sciences, Umeå University, 901 87 Umeå, Sweden
5
Molecular & Clinical Sciences Research Institute, St. George University, London SW17 0RE, UK
*
Author to whom correspondence should be addressed.
Received: 28 October 2017 / Revised: 10 January 2018 / Accepted: 15 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Pathomechanisms of Atherosclerosis)
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Abstract

Background: Coronary artery ectasia (CAE) is a rare disorder commonly associated with additional features of atherosclerosis. In the present study, we aimed to examine the systemic immune-inflammatory response that might associate CAE. Methods: Plasma samples were obtained from 16 patients with coronary artery ectasia (mean age 64.9 ± 7.3 years, 6 female), 69 patients with coronary artery disease (CAD) and angiographic evidence for atherosclerosis (age 64.5 ± 8.7 years, 41 female), and 140 controls (mean age 58.6 ± 4.1 years, 40 female) with normal coronary arteries. Samples were analyzed at Umeå University Biochemistry Laboratory, Sweden, using the V-PLEX Pro-Inflammatory Panel 1 (human) Kit. Statistically significant differences (p < 0.05) between patient groups and controls were determined using Mann–Whitney U-tests. Results: The CAE patients had significantly higher plasma levels of INF-γ, TNF-α, IL-1β, and IL-8 (p = 0.007, 0.01, 0.001, and 0.002, respectively), and lower levels of IL-2 and IL-4 (p < 0.001 for both) compared to CAD patients and controls. The plasma levels of IL-10, IL-12p, and IL-13 were not different between the three groups. None of these markers could differentiate between patients with pure (n = 6) and mixed with minimal atherosclerosis (n = 10) CAE. Conclusions: These results indicate an enhanced systemic pro-inflammatory response in CAE. The profile of this response indicates activation of macrophages through a pathway and trigger different from those of atherosclerosis immune inflammatory response. View Full-Text
Keywords: coronary artery ectasia; atherosclerosis; cytokines; macrophage activation; immune inflammatory response; coronary artery disease coronary artery ectasia; atherosclerosis; cytokines; macrophage activation; immune inflammatory response; coronary artery disease
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Boles, U.; Johansson, A.; Wiklund, U.; Sharif, Z.; David, S.; McGrory, S.; Henein, M.Y. Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis. Int. J. Mol. Sci. 2018, 19, 260.

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