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Int. J. Mol. Sci. 2018, 19(1), 260; doi:10.3390/ijms19010260

Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis

Department of Public Health and Clinical Medicine, Umeå University, 901 87 Umeå, Sweden
Cardiology Department, Letterkenny University Hospital, Letterkenny, F92 AE81, Co. Donegal, Ireland
Molecular Periodontology and Odontology, Umeå University, 901 87 Umeå, Sweden
Department of Radiation Sciences, Umeå University, 901 87 Umeå, Sweden
Molecular & Clinical Sciences Research Institute, St. George University, London SW17 0RE, UK
Author to whom correspondence should be addressed.
Received: 28 October 2017 / Revised: 10 January 2018 / Accepted: 15 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Pathomechanisms of Atherosclerosis)
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Background: Coronary artery ectasia (CAE) is a rare disorder commonly associated with additional features of atherosclerosis. In the present study, we aimed to examine the systemic immune-inflammatory response that might associate CAE. Methods: Plasma samples were obtained from 16 patients with coronary artery ectasia (mean age 64.9 ± 7.3 years, 6 female), 69 patients with coronary artery disease (CAD) and angiographic evidence for atherosclerosis (age 64.5 ± 8.7 years, 41 female), and 140 controls (mean age 58.6 ± 4.1 years, 40 female) with normal coronary arteries. Samples were analyzed at Umeå University Biochemistry Laboratory, Sweden, using the V-PLEX Pro-Inflammatory Panel 1 (human) Kit. Statistically significant differences (p < 0.05) between patient groups and controls were determined using Mann–Whitney U-tests. Results: The CAE patients had significantly higher plasma levels of INF-γ, TNF-α, IL-1β, and IL-8 (p = 0.007, 0.01, 0.001, and 0.002, respectively), and lower levels of IL-2 and IL-4 (p < 0.001 for both) compared to CAD patients and controls. The plasma levels of IL-10, IL-12p, and IL-13 were not different between the three groups. None of these markers could differentiate between patients with pure (n = 6) and mixed with minimal atherosclerosis (n = 10) CAE. Conclusions: These results indicate an enhanced systemic pro-inflammatory response in CAE. The profile of this response indicates activation of macrophages through a pathway and trigger different from those of atherosclerosis immune inflammatory response. View Full-Text
Keywords: coronary artery ectasia; atherosclerosis; cytokines; macrophage activation; immune inflammatory response; coronary artery disease coronary artery ectasia; atherosclerosis; cytokines; macrophage activation; immune inflammatory response; coronary artery disease

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Boles, U.; Johansson, A.; Wiklund, U.; Sharif, Z.; David, S.; McGrory, S.; Henein, M.Y. Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis. Int. J. Mol. Sci. 2018, 19, 260.

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