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Int. J. Mol. Sci. 2017, 18(10), 2034; doi:10.3390/ijms18102034

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

1,2
,
3
,
4,5,6,* and 7,8,9,*
1
Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
2
Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan
3
Research Assistant Center, Show Chwan Memorial Hospital, Changhua 500, Taiwan
4
Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5
Department of Surgery, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung 807, Taiwan
6
Division of Breast Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
7
Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
8
School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei 242, Taiwan
9
National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 7 September 2017 / Revised: 19 September 2017 / Accepted: 19 September 2017 / Published: 22 September 2017
(This article belongs to the Special Issue Pathomechanisms of Atherosclerosis)
View Full-Text   |   Download PDF [1496 KB, uploaded 22 September 2017]   |  

Abstract

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local inflammation. Immune and inflammatory responses have significant effects on every phase of atherosclerosis, and increasing evidence shows that immunity plays a more important role in atherosclerosis by tightly regulating its progression. Therefore, understanding the relationship between immune responses and the atherosclerotic microenvironment is extremely important. This article reviews existing knowledge regarding the pathogenesis of immune responses in the atherosclerotic microenvironment, and the immune mechanisms involved in atherosclerosis formation and activation. View Full-Text
Keywords: atherosclerosis; atherosclerotic immunity; atherosclerotic microenvironment; oxidative stress; macrophage atherosclerosis; atherosclerotic immunity; atherosclerotic microenvironment; oxidative stress; macrophage
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wu, M.-Y.; Li, C.-J.; Hou, M.-F.; Chu, P.-Y. New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis. Int. J. Mol. Sci. 2017, 18, 2034.

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