Galectin-12 in Cellular Differentiation, Apoptosis and Polarization
AbstractGalectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains joined by a linker region. Galectin-12 is predominantly expressed in adipose tissue, but is also detected in macrophages and other leukocytes. Downregulation of galectin-12 in mouse 3T3-L1 cells impairs their differentiation into adipocytes. Conversely, overexpression of galectin-12 in vitro induces cell cycle arrest in G1 and apoptosis. Upregulation of galectin-12 and initiation of G1 cell cycle arrest are associated with driving pre-adipocytes toward terminal differentiation. Galectin-12 deficiency increases insulin sensitivity and glucose tolerance in obese animals. Galectin-12 inhibits macrophage polarization to the M2 population, enhancing inflammation and decreasing insulin sensitivity in adipocytes. Galectin-12 also affects myeloid differentiation, which is associated with chemotherapy resistance. In addition to highlighting the above-mentioned aspects, this review also discusses the potential clinical applications of modulating the function of galectin-12. View Full-Text
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Wan, L.; Yang, R.-Y.; Liu, F.-T. Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. Int. J. Mol. Sci. 2018, 19, 176.
Wan L, Yang R-Y, Liu F-T. Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. International Journal of Molecular Sciences. 2018; 19(1):176.Chicago/Turabian Style
Wan, Lei; Yang, Ri-Yao; Liu, Fu-Tong. 2018. "Galectin-12 in Cellular Differentiation, Apoptosis and Polarization." Int. J. Mol. Sci. 19, no. 1: 176.
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