Proteasome and Organs Ischemia-Reperfusion Injury
AbstractThe treatment of organ failure on patients requires the transplantation of functional organs, from donors. Over time, the methodology of transplantation was improved by the development of organ preservation solutions. The storage of organs in preservation solutions is followed by the ischemia of the organ, resulting in a shortage of oxygen and nutrients, which damage the tissues. When the organ is ready for the transplantation, the reperfusion of the organ induces an increase of the oxidative stress, endoplasmic reticulum stress, and inflammation which causes tissue damage, resulting in a decrease of the transplantation success. However, the addition of proteasome inhibitor in the preservation solution alleviated the injuries due to the ischemia-reperfusion process. The proteasome is a protein structure involved in the regulation the inflammation and the clearance of damaged proteins. The goal of this review is to summarize the role of the proteasome and pharmacological compounds that regulate the proteasome in protecting the organs from the ischemia-reperfusion injury. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Oliva, J. Proteasome and Organs Ischemia-Reperfusion Injury. Int. J. Mol. Sci. 2018, 19, 106.
Oliva J. Proteasome and Organs Ischemia-Reperfusion Injury. International Journal of Molecular Sciences. 2018; 19(1):106.Chicago/Turabian Style
Oliva, Joan. 2018. "Proteasome and Organs Ischemia-Reperfusion Injury." Int. J. Mol. Sci. 19, no. 1: 106.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.