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Int. J. Mol. Sci. 2017, 18(9), 2002; doi:10.3390/ijms18092002

Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms

1
Department of Vascular Biology and Tumor Angiogenesis, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, D-68167 Mannheim, Germany
2
Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), D-69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Received: 16 August 2017 / Revised: 31 August 2017 / Accepted: 14 September 2017 / Published: 19 September 2017
(This article belongs to the Special Issue Glyoxalase System in Health and Disease 2017)
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Abstract

Diabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with its associated organ pathologies, is one of the key problems in today’s medicine. Zebrafish is an upcoming disease model organism in diabetes research. Its glucose metabolism and the pathways of reactive metabolite formation are very similar to those of humans. Moreover, several physiological and pathophysiological pathways that also exist in humans and other mammals have been identified in this species or are currently under intense investigation. Zebrafish offer sophisticated imaging techniques and allow simple and fast genetic and pharmacological approaches with a high throughput. In this review, we highlight achievements and mechanisms concerning microvascular complications discovered in zebrafish, and we discuss the advantages and disadvantages of zebrafish as a model for studying diabetic complications. View Full-Text
Keywords: zebrafish; glyoxalase; diabetes mellitus; hyperglycemia; reactive metabolites zebrafish; glyoxalase; diabetes mellitus; hyperglycemia; reactive metabolites
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Heckler, K.; Kroll, J. Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms. Int. J. Mol. Sci. 2017, 18, 2002.

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