Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms
AbstractDiabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with its associated organ pathologies, is one of the key problems in today’s medicine. Zebrafish is an upcoming disease model organism in diabetes research. Its glucose metabolism and the pathways of reactive metabolite formation are very similar to those of humans. Moreover, several physiological and pathophysiological pathways that also exist in humans and other mammals have been identified in this species or are currently under intense investigation. Zebrafish offer sophisticated imaging techniques and allow simple and fast genetic and pharmacological approaches with a high throughput. In this review, we highlight achievements and mechanisms concerning microvascular complications discovered in zebrafish, and we discuss the advantages and disadvantages of zebrafish as a model for studying diabetic complications. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Heckler, K.; Kroll, J. Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms. Int. J. Mol. Sci. 2017, 18, 2002.
Heckler K, Kroll J. Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms. International Journal of Molecular Sciences. 2017; 18(9):2002.Chicago/Turabian Style
Heckler, Karl; Kroll, Jens. 2017. "Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms." Int. J. Mol. Sci. 18, no. 9: 2002.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.