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Int. J. Mol. Sci. 2017, 18(5), 984; doi:10.3390/ijms18050984

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention

1
Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, 69120 Heidelberg, Germany
2
Department of Nuclear Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany
3
German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany
4
Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz Center, 85764 Munich-Neuherberg, Germany
5
Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
6
Molecular Medicine Partnership Unit, University of Heidelberg, 69120 Heidelberg, Germany
7
Institute for Diabetes and Cancer (IDC), Helmholtz Center, 85764 Munich-Neuherberg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Casper G. Schalkwijk
Received: 25 January 2017 / Revised: 11 April 2017 / Accepted: 2 May 2017 / Published: 5 May 2017
(This article belongs to the Special Issue Glyoxalase System in Health and Disease 2017)
View Full-Text   |   Download PDF [1127 KB, uploaded 5 May 2017]   |  

Abstract

Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented. View Full-Text
Keywords: advanced glycation end-products; diabetes; glyoxalase; aldose reductase; methylglyoxal; glyoxal; 3-deoxyglucosone advanced glycation end-products; diabetes; glyoxalase; aldose reductase; methylglyoxal; glyoxal; 3-deoxyglucosone
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Brings, S.; Fleming, T.; Freichel, M.; Muckenthaler, M.U.; Herzig, S.; Nawroth, P.P. Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention. Int. J. Mol. Sci. 2017, 18, 984.

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