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Int. J. Mol. Sci. 2017, 18(9), 1967; doi:10.3390/ijms18091967

Biological Pathways Involved in Tumor Angiogenesis and Bevacizumab Based Anti-Angiogenic Therapy with Special References to Ovarian Cancer

1
Department of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy
2
Gynecologic Oncology Unit, IRCCS, Istituto Tumori Giovanni Paolo II, 70142 Bari, Italy
3
Department of Pathology, University of Bari, 70121 Bari, Italy
*
Author to whom correspondence should be addressed.
Received: 18 July 2017 / Revised: 16 August 2017 / Accepted: 8 September 2017 / Published: 14 September 2017
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Abstract

The creation of new blood vessels from existing ones, which is a mechanism called “angiogenesis”, is essential in cancer to supply cancerous growth. Moreover, the development and the progression of the tumor and its metastases are the result of an efficient vascular response. Cancer cells release and activate different angiogenic growth factors and their receptors in the tumor microenvironment to promote the angiogenic process. The most important pro-angiogenic factor is the “Vascular Endothelial Growth Factor” (VEGF) because of its mitogen activity on vascular endothelium. Bevacizumab is a monoclonal antibody that obstructs the binding of circulating vascular endothelial growth factor to its receptors and has been approved for the treatment of primary and recurrent ovarian cancer but also for many other solid tumors. View Full-Text
Keywords: angiogenesis; VEGF; ovarian cancer angiogenesis; VEGF; ovarian cancer
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Loizzi, V.; Del Vecchio, V.; Gargano, G.; De Liso, M.; Kardashi, A.; Naglieri, E.; Resta, L.; Cicinelli, E.; Cormio, G. Biological Pathways Involved in Tumor Angiogenesis and Bevacizumab Based Anti-Angiogenic Therapy with Special References to Ovarian Cancer. Int. J. Mol. Sci. 2017, 18, 1967.

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