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Int. J. Mol. Sci. 2017, 18(9), 1963; doi:10.3390/ijms18091963

Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases

1
Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Yang-Ming University and Academia Sinica, Taipei 11529, Taiwan
2
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan
*
Author to whom correspondence should be addressed.
Received: 31 July 2017 / Revised: 1 September 2017 / Accepted: 7 September 2017 / Published: 13 September 2017
(This article belongs to the Special Issue Neuronal Protein Homeostasis in Health and Disease)
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Abstract

Protein homeostasis or proteostasis is a fundamental cellular property that encompasses the dynamic balancing of processes in the proteostasis network (PN). Such processes include protein synthesis, folding, and degradation in both non-stressed and stressful conditions. The role of the PN in neurodegenerative disease is well-documented, where it is known to respond to changes in protein folding states or toxic gain-of-function protein aggregation. Dual-specificity phosphatases have recently emerged as important participants in maintaining balance within the PN, acting through modulation of cellular signaling pathways that are involved in neurodegeneration. In this review, we will summarize recent findings describing the roles of dual-specificity phosphatases in neurodegeneration and offer perspectives on future therapeutic directions. View Full-Text
Keywords: protein homeostasis; dual-specificity phosphatases; neuron; protein aggregates; heat shock response; oxidative stress; ER stress; autophagy protein homeostasis; dual-specificity phosphatases; neuron; protein aggregates; heat shock response; oxidative stress; ER stress; autophagy
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Bhore, N.; Wang, B.-J.; Chen, Y.-W.; Liao, Y.-F. Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases. Int. J. Mol. Sci. 2017, 18, 1963.

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