Next Article in Journal
Redox Properties of Tryptophan Metabolism and the Concept of Tryptophan Use in Pregnancy
Next Article in Special Issue
Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases
Previous Article in Journal
Application of Extrusion-Based Hydrogel Bioprinting for Cartilage Tissue Engineering
Previous Article in Special Issue
Proteostasis of Huntingtin in Health and Disease
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(7), 1596; doi:10.3390/ijms18071596

Autophagy and Human Neurodegenerative Diseases—A Fly’s Perspective

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
*
Authors to whom correspondence should be addressed.
Received: 19 June 2017 / Revised: 12 July 2017 / Accepted: 21 July 2017 / Published: 23 July 2017
(This article belongs to the Special Issue Neuronal Protein Homeostasis in Health and Disease)
View Full-Text   |   Download PDF [449 KB, uploaded 23 July 2017]   |  

Abstract

Neurodegenerative diseases in humans are frequently associated with prominent accumulation of toxic protein inclusions and defective organelles. Autophagy is a process of bulk lysosomal degradation that eliminates these harmful substances and maintains the subcellular environmental quality. In support of autophagy’s importance in neuronal homeostasis, several genetic mutations that interfere with autophagic processes were found to be associated with familial neurodegenerative disorders. In addition, genetic mutations in autophagy-regulating genes provoked neurodegenerative phenotypes in animal models. The Drosophila model significantly contributed to these recent developments, which led to the theory that autophagy dysregulation is one of the major underlying causes of human neurodegenerative disorders. In the current review, we discuss how studies using Drosophila enhanced our understanding of the relationship between autophagy and neurodegenerative processes. View Full-Text
Keywords: Drosophila; neurodegeneration; autophagy; Alzheimer; Parkinson; Huntington; ataxia; protein aggregate; mitochondrial dysfunction Drosophila; neurodegeneration; autophagy; Alzheimer; Parkinson; Huntington; ataxia; protein aggregate; mitochondrial dysfunction
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, M.; Ho, A.; Lee, J.H. Autophagy and Human Neurodegenerative Diseases—A Fly’s Perspective. Int. J. Mol. Sci. 2017, 18, 1596.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top